(−)-Epigallocatechin gallate

Papers

Oral Pre-treatment With Epigallocatechin Gallate In 6-OHDA Lesioned Rats Produces Subtle Symptomatic Relief But Not Neuroprotection. Leaver, K.R., et al. Brain Res. Bull. 80, 397-402, (2009)

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Interaction Of Tea Catechin (-)-epigallocatechin Gallate With Lipid Bilayers. Sun, Y., et al. Biophys. J. 96, 1026-35, (2009)

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(-)-Epigallocatechin Gallate Inhibition Of Osteoclastic Differentiation Via NF-kappaB. Lin, R.W., et al. Biochem. Biophys. Res. Commun. 379, 1033-7, (2009)

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Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells Sánchez-Tena, S., et al. J. Nat. Prod. 75, 26-33, (2012)

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Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials. Marlène Backleh-Sohrt et al J. Nat. Prod. 68, 1386-9, (2005)

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Expanding the ChemGPS chemical space with natural products. Josefin Larsson et al J. Nat. Prod. 68, 985-91, (2005)

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Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. Deniz Tasdemir et al J. Med. Chem. 49, 3345-53, (2006)

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Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing. Ki Sung Kang et al Bioorg. Med. Chem. Lett. 16, 5028-31, (2006)

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Neuroprotective bibenzyl glycosides of Stemona tuberosa roots. Ki Yong Lee et al J. Nat. Prod. 69, 679-81, (2006)

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Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. Helena Gradisar et al J. Med. Chem. 50, 264-71, (2007)

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Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). Shailendra Kumar Sharma et al J. Med. Chem. 50, 765-75, (2007)

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Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity. Takumi Furuta et al Bioorg. Med. Chem. Lett. 17, 3095-8, (2007)

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A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer. Kumi Osanai et al Bioorg. Med. Chem. 15, 5076-82, (2007)

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A novel fluorescence intensity screening assay identifies new low-molecular-weight inhibitors of the gp41 coiled-coil domain of human immunodeficiency virus type 1. Lifeng Cai et al Antimicrob. Agents Chemother. 51, 2388-95, (2007)

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Antifibrotic phenanthrenes of Dendrobium nobile stems. Hyekyung Yang et al J. Nat. Prod. 70, 1925-9, (2007)

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Mai Nguyen et al Proc. Natl. Acad. Sci. U. S. A. 104, 19512-7, (2007)

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Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate. Luís Sánchez-del-Campo et al J. Med. Chem. 51, 2018-26, (2008)

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Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length. Shuichi Mori et al Bioorg. Med. Chem. Lett. 18, 4249-52, (2008)

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New polyphenols active on beta-amyloid aggregation. Céline Rivière et al Bioorg. Med. Chem. Lett. 18, 828-31, (2008)

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Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Eui Seok Shin et al Bioorg. Med. Chem. 16, 3580-6, (2008)

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Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Tomohiro Itoh et al Bioorg. Med. Chem. 16, 7592-8, (2008)

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Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate. Kosuke Dodo et al Bioorg. Med. Chem. 16, 7975-82, (2008)

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Time-dependent intracellular trafficking of FITC-conjugated epigallocatechin-3-O-gallate in L-929 cells. Dong-Wook Han et al Bioorg. Med. Chem. 16, 9652-9, (2008)

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Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus. Charles E Isaacs et al Antimicrob. Agents Chemother. 52, 962-70, (2008)

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Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. Christine A Larsen et al J. Med. Chem. 52, 6543-5, (2009)

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Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Yoshiyuki Aihara et al Bioorg. Med. Chem. Lett. 19, 4171-4, (2009)

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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Ashley A Reinke et al Bioorg. Med. Chem. Lett. 19, 4952-7, (2009)

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Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives. Sungbum Kim et al Bioorg. Med. Chem. Lett. 19, 508-12, (2009)

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Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line. Yuanming Lu et al Bioorg. Med. Chem. 17, 1709-15, (2009)

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Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3. Tomohiro Itoh et al Bioorg. Med. Chem. 17, 5374-9, (2009)

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The role of phenolic hydroxy groups in the free radical scavenging activity of betalains. Fernando Gandía-Herrero et al J. Nat. Prod. 72, 1142-6, (2009)

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Emerging targets in osteoporosis disease modification. John G Allen et al J. Med. Chem. 53, 4332-53, (2010)

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New inhibitors for expression of IgE receptor on human mast cell. Satoru Tamura et al Bioorg. Med. Chem. Lett. 20, 2299-302, (2010)

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Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Guang-Hua Xu et al Bioorg. Med. Chem. Lett. 20, 513-5, (2010)

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Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. He Zhong Jiang et al Bioorg. Med. Chem. Lett. 20, 6045-7, (2010)

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Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. Congde Huo et al Bioorg. Med. Chem. 18, 1252-8, (2010)

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Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation. John A Carver et al Bioorg. Med. Chem. 18, 222-8, (2010)

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Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids. Dragan Ami? et al Bioorg. Med. Chem. 18, 28-35, (2010)

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Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin. Takeshi Ishii et al Bioorg. Med. Chem. 18, 4892-6, (2010)

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2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Deniz Tasdemir et al Bioorg. Med. Chem. 18, 7475-85, (2010)

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Synthesis and antimicrobial activities of 3-O-alkyl analogues of (+)-catechin: improvement of stability and proposed action mechanism. Ki Duk Park et al Eur. J. Med. Chem. 45, 1028-33, (2010)

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Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5?-reductase inhibitors. Shu Fu Lin et al Eur. J. Med. Chem. 45, 6068-76, (2010)

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Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties. Cleber A Schmidt et al J. Nat. Prod. 73, 2035-41, (2010)

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Discovery of indeno[1,2-c]quinoline derivatives as inhibitors of osteoclastogenesis induced by receptor activator of NF-?B ligand (RANKL). Chih-Hua Tseng et al J. Med. Chem. 54, 3103-7, (2011)

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Lysine demethylases inhibitors. Takayoshi Suzuki et al J. Med. Chem. 54, 8236-50, (2011)

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Antifibrotic constituents of Alnus firma on hepatic stellate cells. Mina Lee et al Bioorg. Med. Chem. Lett. 21, 2906-10, (2011)

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Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. Lei You et al Bioorg. Med. Chem. Lett. 21, 3007-11, (2011)

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Phenolic substances from Phagnalon rupestre protect against 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity. Elisa Giner et al J. Nat. Prod. 74, 1079-84, (2011)

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(-)-Epigallocatechin-3-O-gallate induces nonapoptotic cell death in leukemia cells independent of the 67 kDa laminin receptor. Masaharu Hazawa et al J. Nat. Prod. 74, 695-700, (2011)

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Antiproliferative triterpenes from the leaves and twigs of Juglans sinensis on HSC-T6 cells. Heejung Yang et al J. Nat. Prod. 74, 751-6, (2011)

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The green tea polyphenol (2)-epigallocatechin-3-gallate (EGCG) is not a ?-secretase inhibitor. Xiao-Rui Cheng et al Bioorg. Med. Chem. Lett. 22, 1408-14, (2012)

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Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay. Di Wang et al Bioorg. Med. Chem. Lett. 22, 168-71, (2012)

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Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents. Cheng-Shi Jiang et al Bioorg. Med. Chem. Lett. 22, 2226-9, (2012)

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Synthesis and antiviral activity of substituted quercetins Thapa, M., et al. Bioorg. Med. Chem. Lett. 22, 353-356, (2011)

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Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase. Md Maniruzzaman Manir et al Bioorg. Med. Chem. 20, 2376-81, (2012)

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Merck 14,3526