|Related Categories||Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Bioflavonoids,|
|solubility||H2O: ≥5 mg/mL, clear|
|Gene Information||human ... CYP1A2(1544)|
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Antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations
Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Cancer, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Transcription
DNA methyltransferases are a family of enzymes that catalyze the transfer of a methyl group to DNA. There are five related DNA cytosine-5-methyltransferases (DNMTs) that transfer a methyl group from ...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 7–9
Keywords: Gene expression, Methylations, PAGE
Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer. Oxidative cellular ...
BioFiles 2007, 2.4, 14.
Keywords: Acetylations, Adhesion, Angiogenesis, Apoptosis, Cancer, Carcinogens, Catalysis, Cell culture, Cell proliferation, Cell signaling, Cellular processes, Degradations, Diabetes, Diseases, Environmental, Gene expression, Glycosylations, High performance liquid chromatography, Inflammation, PAGE, Phosphorylations, Thin layer chromatography, Transcription, transformation
Green tea catechins based functional drink (Green cool) improves the antioxidant status of SD rats fed on high cholesterol and sucrose diets. Ahmad RS, Butt MS, Huma N, et al. Pak. J. Pharm. Sci. 26(4), 721-6, (2013)
[Results of open multicenter study of the safety of doxazosin in combination with indigal in men with stages I-II prostatic adenoma]. Pavlov VN, Komiakov BK, Grigor'ev MÉ, et al. Urologiia. (2), 42-4, 46, (2013)
Epigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behaviour of triple negative breast cancer cells. Braicu C, Gherman CD, Irimie A, et al. J. Nanosci. Nanotechnol. 13(1), 632-7, (2013)
Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated Src and Janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells. Zgheib A, Lamy S, and Annabi B J. Biol. Chem. 288(19), 13378-86, (2013)
Effect and mechanism of epigallocatechin-3-gallate (EGCG). against the hydrogen peroxide-induced oxidative damage in human dermal fibroblasts. Feng B, Fang Y, and Wei SM J. Cosmet. Sci. 64(1), 35-44, (2013)
Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet. Cunha CA, Lira FS, Rosa Neto JC, et al. Mediators Inflamm. 2013, 635470, (2013)
Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Hyung SJ, DeToma AS, Brender JR, et al. Proc. Natl. Acad. Sci. U. S. A. 110(10), 3743-8, (2013)
TGF-β1-induced epithelial-mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung cancer cells. Ko H, So Y, Jeon H, et al. Cancer Lett. 335(1), 205-13, (2013)
[(-)-Epigallocatechin gallate regulates expression of apoptotic genes and protects cultured human lens epithelial cells under hyperglycemia]. Ye P, Lin K, Li Z, et al. Mol. Biol. (Mosk.) 47(2), 251-7, (2013)
Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism. Moreira L, Araújo I, Costa T, et al. Exp. Cell Res. 319(12), 1784-95, (2013)
Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. Papi A, Farabegoli F, Iori R, et al. Food Chem. 138(2-3), 1521-30, (2013)
EGCG attenuates high glucose-induced endothelial cell inflammation by suppression of PKC and NF-κB signaling in human umbilical vein endothelial cells. Yang J, Han Y, Chen C, et al. Life Sci. 92(10), 589-97, (2013)
The activity against Ehrlich's ascites tumors of doxorubicin contained in self assembled, cell receptor targeted nanoparticle with simultaneous oral delivery of the green tea polyphenol epigallocatechin-3-gallate. Ray L, Kumar P, and Gupta KC Biomaterials 34(12), 3064-76, (2013)
Bi-layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application: in-vitro and in-vivo studies. Jaiswal M, Gupta A, Agrawal AK, et al. J. Biomed. Nanotechnol. 9(9), 1495-508, (2013)
Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma. Volta V, Ranzato E, Martinotti S, et al. PLoS ONE 8(3), e58051, (2013)
Epigallocatechin gallate attenuated the activation of rat cardiac fibroblasts induced by angiotensin II via regulating β-arrestin1. Han YS, Lan L, Chu J, et al. Cell Physiol. Biochem. 31(2-3), 338-46, (2013)
Synergistic interactions of epigallocatechin gallate and oxytetracycline against various drug resistant Staphylococcus aureus strains in vitro. Novy P, Rondevaldova J, Kourimska L, et al. Phytomedicine 20(5), 432-5, (2013)
The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Caporali A, Davalli P, Astancolle S, et al. Carcinogenesis 25(11), 2217-24, (2004)
Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy. Dorchies OM, Wagner S, Vuadens O, et al. Am. J. Physiol. Cell Physiol. 290(2), C616-25, (2006)
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. Rezai-Zadeh K, Shytle D, Sun N, et al. J. Neurosci. 25(38), 8807-14, (2005)
Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 (4N1-1) is inhibited by epigallocatechin gallate but not by prostaglandin E1. Neuhaus T, Voit S, Lill G, et al. Platelets 15(7), 455-7, (2004)
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Katiyar SK, Matsui MS, Elmets CA, et al. Photochem. Photobiol. 69(2), 148-53, (1999)
Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin. Dvorakova K, Dorr RT, Valcic S, et al. Cancer Chemother. Pharmacol. 43(4), 331-5, (1999)
Identification and characterization of methylated and ring-fission metabolites of tea catechins formed in humans, mice, and rats. Meng X, Sang S, Zhu N, et al. Chem. Res. Toxicol. 15(8), 1042-50, (2002)
Green tea-induced asthma: relationship between immunological reactivity, specific and non-specific bronchial responsiveness. Shirai T, Reshad K, Yoshitomi A, et al. Clin. Exp. Allergy 33(9), 1252-5, (2003)
Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Katiyar SK, Afaq F, Perez A, et al. Carcinogenesis 22(2), 287-94, (2001)
A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer. Kumi Osanai et al Bioorg. Med. Chem. 15, 5076-82, (2007)
A novel fluorescence intensity screening assay identifies new low-molecular-weight inhibitors of the gp41 coiled-coil domain of human immunodeficiency virus type 1. Lifeng Cai et al Antimicrob. Agents Chemother. 51, 2388-95, (2007)
Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length. Shuichi Mori et al Bioorg. Med. Chem. Lett. 18, 4249-52, (2008)
Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination. Tomohiro Itoh et al Bioorg. Med. Chem. 16, 7592-8, (2008)
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. Christine A Larsen et al J. Med. Chem. 52, 6543-5, (2009)
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