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E4389 Sigma

β-Estradiol-Water Soluble

BioReagent, suitable for cell culture

Synonym: Cyclodextrin-encapsulated 17β-estradiol



Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen,
product line   BioReagent
solubility   H2O: 25 mg/mL clear to slightly hazy
suitability   suitable for cell culture


Frequently Asked Questions

Frequently Asked Questions are available for this Product.


β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). This product is not recommended for use in binding assays.

Other Notes

Contains 40-55 mg estradiol per gram of solid; balance 2-hydroxypropyl-β-cyclodextrin.


100 mg in poly bottle

Package size based on estradiol

Price and Availability

All labs need water
Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
UN 3077 9 / PGIII
WGK Germany 

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
How do I calculate the molarity of product E4389, β-Estradiol - Water Soluble?
Product E4389 (β-Estradiol-Water Soluble) is a complex of β-Estradiol and cyclodextrin. Cyclodextrin is used to aid in the solubility of β-Estradiol into water. In order to prepare a molar solution of β-Estradiol you will have to base it on the β-Estradiol content in the solution and not the entire complex.  Product E4389 is formulated to contain 40 - 55 mg β-Estradiol per gram of powder (we will use 48 mg in the example).  Based on this average, if you are preparing a 25 mg/ml stock solution, there will be approximately 1.2 mg of β-Estradiol in 1 ml.  Below is the calculated molarity of β-Estradiol when the complex is dissolved at 25 mg/ml in water.  molecular weight X unknown molarity X volume = complex weight X complex ratio 272.38 g/mol X Molarity X 1 ml = 25 mg X 0.048          Molarity = 0.004 M β-Estradiol molecular weight = 272.38 g/mol molarity (unknown) = mol/L volume = 1ml complex weight = 25 mg complex ratio = 48 mg β-Estradiol/1 gm complex
  What kind of solution is the A5955 - Antibiotic Antimycotic Solution (100×), Stabilized product suspended in?
A5955 - Antibiotic Antimycotic Solution (100×), Stabilized is supsended in a sodium citrate buffer solution. Source: Israel production group
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C0926 (2-Hydroxypropyl)-β-cyclodextrin, powder, BioReagent, suitable for cell culture

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