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  • E4777 - Anti-β−Epithelial Cell Sodium Channel antibody produced in rabbit

E4777 Sigma

Anti-β−Epithelial Cell Sodium Channel antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-β−ENaC



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Ion Channels, Antibodies to Sodium Channels,
species reactivity   rat
application(s)   immunoprecipitation: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 75 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... SCNN1B(6338)
rat ... Scnn1b(24767)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 619-640 of human β-ENaC.

Physical form

Solution in phosphate buffered saline containing 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.


Anti-β-Epithelial Cell Sodium Channel antibody produced in rabbit is suitable for immunoprecipitation.

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Biochem/physiol Actions

Sodium channel, non-voltage-gated 1, β subunit (ENaC) is encoded by SCNN1B gene in humans. It is one of the three subunits that form the epithelial sodium channel. ENaC plays an important role in trophoblast cell invasion and migration. Lower expression and activity of epithelial sodium channel in trophoblast cells may be involved in the pathogenesis of preeclampsia. It may be a common underlying pathway for the development of primary hypertension. ENaC is also associated with Cystic fibrosis (CF), which is caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene.

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