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E4902 Sigma

Anti-γ-Epithelial Cell Sodium Channel antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-γ-ENaC

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Ion Channels, Antibodies to Sodium Channels,
species reactivity   rat
application(s)   immunoprecipitation: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 75 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... SCNN1G(6340)
rat ... Scnn1g(24768)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 630-649 of human γ-ENaC.

Physical form

Solution in phosphate buffered saline containing 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

Application

Anti-γ-Epithelial Cell Sodium Channel antibody produced in rabbit is suitable for the following applications:
• Immunoprecipitation
• Western blotting
• Immunoblotting

Features and Benefits

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Biochem/physiol Actions

The epithelial sodium channel (ENaC) is expressed in sodium-absorbing epithelia and also found in ocular tissues. It may play an important role in aqueous humor secretion and glaucoma. There are four ENaC subunits (αβγδ) and are expressed in the normal human eye. ENaC activation by proteases may be involved in cystic fibrosis, sodium retention and the pathogenesis of arterial hypertension in the context of renal disease. The γ-subunit of the epithelial sodium channel (SCNN1G) are associated with both mendelian and quantitative effects on blood pressure. It helps in blood pressure determination.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
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References

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