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  • E5017 - Anti-LPA1, C-Terminal antibody produced in rabbit

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E5017 Sigma

Anti-LPA1, C-Terminal antibody produced in rabbit

~1 mg/mL, IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-EDG-2, Anti-Endothelial Cell Differentiation Gene 2

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, LM-LRP,
species reactivity   human, rat
application(s)   western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~50 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... LPAR1(1902)
rat ... Lpar1(116744)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 328-344 of human EDG-2/LPA1.

Physical form

Solution in 0.2 mM sterile-filtered Ca2+- and Mg2+- free Dulbecco′s PBS, containing 0.05% sodium azide

Application

Anti-LPA1, C-Terminal antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain microsomal fraction.

Features and Benefits

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Biochem/physiol Actions

Lysophosphatidic acid receptor 1 (LPA1) is a protein encoded by the LPAR1 gene in humans. It is constitutively localized in the nucleus of mammalian cells and may be involved in regulating intranuclear protein phosphorylation and signalling. LPA1 is differentially expressed in androgen-insensitive and LPA-responsive cells. It is not expressed in androgen-dependent and LPA-resistant cells.Its expression is significantly higher in the cancer compared with the benign tissues and may possibly act as a drug target to interfere with progression of prostate cancer. LPA1 helps in promoting cell proliferation, survival and migration by acting on cognate G protein-coupled receptors.

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