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  • E5900 - Monoclonal Anti-c-erbB-4 antibody produced in mouse

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E5900 Sigma

Monoclonal Anti-c-erbB-4 antibody produced in mouse

~2 mg/mL, clone HER4-36, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-HER-4

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   immunoprecipitation: 4-8 μg/test using RIPA lysate of cultured CB4 cells (CHO cell line transfected with erbB-4)
  microarray: suitable
clone   HER4-36, monoclonal
concentration   ~2 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 180-185 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ERBB4(2066)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

extracellular domain of human erbB-4 from transfected cells.

General description

ErbB-4 also refers as HER4 is a 180-185kD oncogene that belongs to epidermal growth factor receptor family and is expressed mainly in several breast carcinoma cell lines, heart, brain, cerebellum, pituitary and in normal skeletal muscle. It plays a crucial role as a cell surface receptor for neuregulins. It can also bind with erbB -2 to forms heterodimers and can modulate ligand affinity. Monoclonal anti-c-erbB-4 antibody can be used to study the role of erbB-4 and its interaction with other erbB family members as well as the cellular and molecular mechanisms underlying tumor growth. Mouse anti-c-erbB-4 antibody reacts specifically with human c-erbB-4 protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Monoclonal anti-c-erbB-4 antibody can be used in immunoprecipitation (4-8 μg/test) using RIPA lysate of cultured CB4 cells (CHO cell line transfected with erbB-4). It can also be used in microarray.

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