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E6136 Sigma

α-Endorphin human

≥97% (HPLC)

Synonym: β-Lipotropin (61-76), human, synthetic, β-Lipotropin 61-76, LPH (61-76), Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr

  • CAS Number 59004-96-5

  • Empirical Formula (Hill Notation) C77H120N18O26S

  • Molecular Weight 1745.95

  •  MDL number MFCD00076381

  •  PubChem Substance ID 24894621

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Endorphins, Mass Spectrometry, Molecular Biology,
InChI Key   NXSIJWJXMWBCBX-NWKQFZAZSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... POMC(5443)

Description

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr

Other Notes

Lyophilized from 0.1% TFA in H2O

Biochem/physiol Actions

α-Endorphin is a substrate for transglutaminase, and has stimulatory effects on immune system function. It influences the self-stimulating tendencies in rat, related to electrical stimulation of the ventral tegmentum area neurons. It counteracts the effect of γ-endorphin and promotes this behavior in rats. The functionality of α-endorphin is comparable to that of psychostimulant drugs, and as it acts in an opposing manner to γ-endorphin, these peptides might have a central role in the homeostasis of brain function.

General description

α-Endorphin is one of the three endorphins found in the brain, which has morphine-mimetic activities. It is a hexadecapeptide with a primary structure of H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-SerGln-Thr-Pro-Leu-Val-Thr-OH. It is a fragment of β-Endorphin (β-LPH61-91), which is an endogenous opioid ligand, and is denoted as (β-LPH61-76). It is found in the hypothalamus and pituitary.

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