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E6900 Sigma

Anti-EphA4 antibody produced in goat

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Angiogenesis, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   mouse
application(s)   indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Epha4(13838)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant mouse EphA4, extracellular domain, expressed in NSO cells.

General description

By immunoblotting and ELISA, the antibody shows ~10% cross-reactivity with recombinant human ephrin-A5 and <5% cross-reactivity with recombinant human EphA1, mouse EphA2, mouse EphA3, rat EphA5, mouse EphA6, mouse EphA7, and mouse EphA8.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

EPH receptor A4 is a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. It binds the ephrin-A and ephrin-B ligands and regulates developmental events, particularly those of the nervous system. EphA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.

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