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E7019 Sigma

Exendin-3

≥97%

  • CAS Number 130357-25-4

  • Empirical Formula (Hill Notation) C184H282N50O61S

  • Molecular Weight 4202.57

  •  MDL number MFCD00240170

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Description

Amino Acid Sequence

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Other Notes

Originally isolated from Heloderma horridum (Gila monster lizard) venom.

Application

Exendin-3 has been used to assess its effect in glucagon receptor knockout mice (Gcgr-/-) and wild-type mice, on glucose-stimulated insulin secretion.

General description

Exendin-3 is a pancreatic secretagogue, which is a member of the glucagon family. It is found in the venom of Heloderma horridurn, which is a Gila monster lizard. It has a molecular mass of 4200Da and is composed of 39 amino acids. 12 amino-acids region in its N-terminal is highly homologous to secretin. Its C-terminal contains an amide group.

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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