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E7031 Sigma

Anti-EZH2 (N-terminal) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-ENX-1, Anti-Enhancer of zeste homolog 2 (Drosophila)

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Epigenetics, Antibodies for Gene Regulation,
species reactivity   mouse, human
application(s)   western blot: 1:500-1:1,000 using K562 cell lysates
  western blot: 1:500-1:1,000 using NIH3T3 cell lysates
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 100 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... EZH2(2146)
mouse ... Ezh2(14056)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 1-14 of human EZH2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Application

Anti-EZH2 (N-terminal) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:1,000 using K562 cell lysates and NIH3T3 cell lysates.

Features and Benefits

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Biochem/physiol Actions

Histone-lysine N-methyltransferase EZH2 is an enzyme encoded by the EZH2 gene in humans. It belongs to the multiprotein polycomb repressive complex 2. Enhancer of zeste homologue 2 (EZH2) is crucially involved in epigenetic silencing by acting as a histone methyltransferase. It is overexpressed in many cancers and is involved in malignant cell proliferation and invasion. EZH2 may be associated with senescence and apoptosis in gastric cancer. It may act as a valuable biomarker for the diagnosis and prognosis of gastric cancer. EZH2 may have function in regulation of gene transcription and chromatin structure.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

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E6906 Anti-EZH2 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

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