• USA Home
  • E7131 - [D-Ala2, D-Leu5]-Enkephalin acetate salt

EMAIL THIS PAGE TO A FRIEND
E7131 Sigma

[D-Ala2, D-Leu5]-Enkephalin acetate salt

≥95% (HPLC)

Synonym: DADLE

Purchase

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enkephalins, Neuropeptides, Opioid Peptides,
InChI Key   YRZBXSPTRALQEX-IIKZURRYSA-N
assay   ≥95% (HPLC)
storage temp.   −20°C
Gene Information   human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)

Description

Amino Acid Sequence

Tyr-Ala-Gly-Phe-Leu

Application

[D-Ala2, D-Leu5]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.

Biochem/physiol Actions

[D-Ala2, D-Leu5]-Enkephalin can induce hibernation in ground squirrels, during summers, when they do not normally hibernate. In multiorgan block preparation, it can prolong the survival time of organs such as, heart, lung, liver, spleen and kidney, up to 46hrs. It aids in tolerance development of myocardium to ischemia. It might have tissue protective role in central nervous system. It prevents and reverses methamphetamine (METH)-induced damage of dopaminergic terminals of brain. It prevents naltrexone-sensitive PC12 cell apoptosis in serum deprivation conditions. Thus, it might play an essential role in the survival of neurons and organs.

General description

[D-Ala2, D-Leu5]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.

Price and Availability


Amplified Detection

Neuroscience Grant Programm

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?