E7144 Sigma

Exendin-4

≥97%

DOWNLOAD MSDS (PDF)
  • CAS Number 141758-74-9

  • Empirical Formula (Hill Notation) C184H282N50O60S

  • Molecular Weight 4186.57

  •  MDL number MFCD00240171

Description

Amino Acid Sequence

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

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Other Notes

Originally isolated from Heloderma suspectum (Gila monster lizard) venom.

Biochem/physiol Actions

Exendin-4, a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors.

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