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  • E7278 - Anti-S1P2, C-Terminal antibody produced in rabbit

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E7278 Sigma

Anti-S1P2, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Synonym: Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, Primary Antibodies,
species reactivity   human
application(s)   western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   fractionated antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~42 kDa by SDS-PAGE
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... S1PR2(9294)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P2 receptor.

Physical form

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

Application

Anti-S1P2, C-Terminal antibody produced in rabbit is suitable for western blotting.

Features and Benefits

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Biochem/physiol Actions

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

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