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E7384 Sigma

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt

≥97% (HPLC)

Synonym: DAGO, DAMGO, Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol

  • CAS Number 100929-53-1

  • Empirical Formula (Hill Notation) C26H35N5O6

  • Molecular Weight 513.59

  •  MDL number MFCD00133215

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enkephalins, Neuropeptides, Opioid Peptides,
InChI Key   XZZYKCKUDLGXJA-NJUGUJQKSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... OPRM1(4988)
mouse ... OPRM1(18390)
rat ... OPRM1(25601)

Description

Amino Acid Sequence

Tyr-Ala-Gly-Nme-Phe-Gly-ol

Biochem/physiol Actions

Enkephalin analog that is a selective agonist at μ-opioid receptors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO has been used:
• for use as a positive control in the assay of G-protein activation with μ-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO
• for the determination of the suppression of contraction by opioid receptors
• to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats

General description

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the μ-opioid receptor. μ-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as β-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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