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  • E7528 - Anti-S1P5, C-Terminal antibody produced in rabbit

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E7528 Sigma

Anti-S1P5, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Synonym: Anti-EDG-8, Anti-Endothelial Cell Differentiation Gene 8

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, Primary Antibodies,
species reactivity   human
application(s)   western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   fractionated antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~42 kDa by SDS-PAGE
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... S1PR5(53637)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-8/S1P5 receptor.

Physical form

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

Application

Anti-S1P5, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using RH7777 cells transfected with full length human EDG-8.

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Biochem/physiol Actions

Sphingosine-1-phosphate receptor 5 (S1PR5) is a human gene which encodes a G protein-coupled receptor. It binds to lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR5 regulates NK cell migration and distribution by interacting with sphingosine-1-phosphate (S1P). In brain endothelial cells (ECs), it contributes to optimal barrier formation and maintains immune quiescence of the barrier endothelium. S1PR5 is localized in the centrosome of mammalian cells and may participate in regulating mitosis. It may function as an intracellular target of S1P linked to regulation of mitosis.

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