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  • E7653 - Anti-S1P4, C-Terminal antibody produced in rabbit

E7653 Sigma

Anti-S1P4, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Synonym: Anti-EDG-6, Anti-Endothelial Cell Differentiation Gene 6



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, Primary Antibodies,
species reactivity   human
application(s)   western blot: suitable
clone   polyclonal
concentration   ~1 mg/mL
antibody form   fractionated antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~45 kDa by SDS-PAGE
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... S1PR4(8698)
biological source   rabbit
conjugate   unconjugated



synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-6/S1P4 receptor.

Physical form

Supplied in phosphate buffered saline, pH 7.3, and 0.08% sodium azide.


Anti-S1P4, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using COS cells transfected with full length EDG-6.

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Biochem/physiol Actions

Sphingosine-1-phosphate receptor 4 (S1PR4, EDG-6) is a human gene which encodes a G protein-coupled receptor and is identified as an orphan G-protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is expressed in lymphoid, hematopoietic tissue and in the lung. EDG-6 acts as a high affinity receptor for SPP that couples to a G(i/o) protein leading to the activation of growth-related signaling pathways. It is one of the S1P or lysosphingolipid receptors that couples to phospholipase C-Ca2+ system through pertussis toxin-sensitive G-proteins.

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WGK Germany  -
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