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E7902 Sigma

EphA1/Fc Chimera human

recombinant, expressed in NSO cells, lyophilized powder

Synonym: Eck, Eph

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in NSO cells
form   lyophilized powder
mol wt   monomer calculated mol wt 84 kDa
  mol wt ~110 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   human ... EPHA1(2041)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse ephrin-A1/Fc in an ELISA assay.

Biochem/physiol Actions

EphA1 is a member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1; involved in pattern formation and morphogenesis.

EphA1 (ephrin receptor A1) has an essential role during development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as a differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.

Other Notes

Extracellular domain of human EphA1 (amino acids 1-547) fused by means of a polypeptide linker to the Fc region of human IgG1 that is histidine-tagged at the C-terminus.

Physical form

Lyophilized from a 0.2 μm filtered solution in Tris, pH 8.

General description

EphA1 (ephrin receptor A1) is a receptor tyrosine kinase (RTK), that belongs to the ephrin receptor family. It is the largest group of receptors in RTK family. This protein has extracellular domain containing the N-terminal, an α-helical single transmembrane region, and a cytoplasmic kinase domain containing the C-terminal. It was the first member of this family to be identified, and is localized to human chromosome. It has a wide range of tissue expression such as, thymus, lung, kidney, small intestinal, bladder, and colon.

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Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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