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E8402 Sigma

EphA5/Fc Chimera from rat

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: Bsk, Cek7, Ehk1, Hek7, Rek7

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in NSO cells
assay   >95% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 84 kDa
  mol wt ~110 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   rat ... Epha5(79208)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse ephrin-A2/Fc in an ELISA assay.

Biochem/physiol Actions

Member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4, and ephrin-A5; involved in pattern formation and morphogenesis.

EphA5 (ephrin receptor A5) is involved in the maintenance and development of differentiated neurons in the adult central nervous system. In ventromedial hypothalamus, alterations in synaptic plasticity and interactions of EphA5 might result in aberration of glucagon secretion, and responses to recurrent hypoglycemia. It is involved in cellular response to irradiation/ genotoxic stimuli, and lung cancer cells with inactivated EphA5 have aberrant G1/S cell cycle checkpoint. This protein is also up-regulated in lung cancer cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

General description

EphA5 (ephrin receptor A5) is a receptor tyrosine kinase, which is a member of the ephrin receptor family. This family is divided into two classes A and B. EphA5 belongs to EphA group, which contains 10 members. The ligands to this group of receptors are glycosylphosphatidylinositol (GPI)-anchored named ephrin-A1-A6. It is a highly regulated gene, and is expressed in both developing and adult central nervous system. In rat brain, three variants of EphA5 mRNA are found, with sizes 8.5, 5.9 and 5.1kb. In adult brain, it is expressed in deep cerebellar nuclei in the large neurons, hippocampus, cerebral cortex, and in cerebellum in the Purkinje and granular cells.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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