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E8403 Sigma

Eotaxin−Biotin from mouse

lyophilized powder

Synonym: SCYA11

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Description

Other Notes

Mouse sequence biotinylated on the C-terminus.

Biochem/physiol Actions

Eotaxin is a chemoattractant for eosinophils, and is involved in inflammatory diseases, such as asthma. It is induced by glucocorticoids and cytokines. Along with interleukin-5 (IL-5), it results in airway hyperresponsiveness (AHR), and hence, lung inflammatory disorders. In humans, it leads to respiratory syncytial virus (RSV) vaccine-enhanced disease, and the eosinophils are also responsible for the elimination of virus. It might also be involved in the pathophysiology of inflammatory bowel diseases, which involve eosinophils. It can lead to the production of reactive oxygen species, thus, resulting in damaged lung tissue. It is overexpressed in multiple diseases such as allergic rhinitis, nasal polyposis, endometriosis and Hodgkin′s disease.

Potent inducer of eosinophil chemotaxis. Causes accumulation of eosinophils in response to parasitic and viral reactions.

General description

Eotaxin is a member of the CC chemokine family, and belongs to the MCP/eotaxin subfamily. It has wide range of tissue expression, such as thymus, heart, lungs, lymph nodes, kidney, and intestines. It is also expressed by epithelial cells of lung, pleural mesothelial cells, epithelial cells of bronchial airway, and smooth muscle cells (SMCs). This gene maps to human chromosome 17q21.1-q21.2.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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