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E8527 Sigma

EphA6/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: Ehk2, Hek12

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 86 kDa
  mol wt ~100 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Epha6(13840)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant human ephrin-A3/Fc in an ELISA assay.

Biochem/physiol Actions

Member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4, and ephrin-A5; involved in pattern formation and morphogenesis.

EphA6 (ephrin receptor A6) is a frequently mutated gene in colorectal cancer, in African-American population. In developing human retina, it is found in the ganglion cells of macula. It is involved in repellant-signaling, and hence, is involved in vascular patterning of retina, and also maintaining postnatal projection from ganglion cells of macula and fovea.

Other Notes

Extracellular domain of mouse EphA6 (amino acids 1-546) fused by means of a polypeptide linker to the Fc region of human IgG1 that is histidine-tagged at the C-terminus.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

General description

EphA6 (ephrin receptor A6) is a receptor tyrosine kinase (RTK), which belongs to a 16 member family of ephrin receptors. This family is divided into two classes A and B. EphA5 belongs to EphA group, which contains 10 members. The ligands to this group of receptors are glycosylphosphatidylinositol (GPI)-anchored named ephrin-A1-A6. The members of this family have an ephrin-binding domain in its N-terminal globular domain, succeeded by a linker region rich in cysteine and two fibronectin type III repeats in the exoplasmic domain. Its cytoplasmic domain consists of a juxtamembrane region, a conserved tyrosine kinase domain, an α-helical C-terminal domain, and a PDZ domain-binding domian.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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