E8534 Sigma


≥98% (HPLC)

Synonym: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid

  • CAS Number 136164-66-4

  • Empirical Formula (Hill Notation) C21H30O6

  • Molecular Weight 378.46

  •  MDL number MFCD00901331


Related Categories Cell Biology, Cell Signaling and Neuroscience, Cell Stress, DNA Repair Proteins and Reagents, DNA-RNA Transcription Regulators,
assay   ≥98% (HPLC)
form   powder
color   red to orange
solubility   DMSO: >20 mg/mL
storage temp.   2-8°C


Biochem/physiol Actions

E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.

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