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E8640 Sigma

E-64d

protease inhibitor

Synonym: (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, EST

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GHS07  GHS07
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WGK Germany 
2
RTECS 
RR0404300

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References

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Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. McGowan, E.B., et al. Biochem. Biophys. Res. Commun. 158, 432, (1989)

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Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats Tsubokawa, T., et al. J. Neurosci. Res. 84, 832-80, (2006)

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Giardia duodenalis cathepsin B proteases degrade intestinal epithelial interleukin-8 and attenuate interleukin-8-induced neutrophil chemotaxis. Cotton JA, Bhargava A, Ferraz JG, et al. Infect. Immun. 82(7), 2772-87, (2014)

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Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus. Yang Y, Du L, Liu C, et al. Proc. Natl. Acad. Sci. U. S. A. 111(34), 12516-21, (2014)

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Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells. Sobol A, Galluzzo P, Liang S, et al. J. Cell Physiol. 230(5), 1064-74, (2015)

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Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway. Caì Y, Postnikova EN, Bernbaum JG, et al. J. Virol. 89(1), 844-56, (2014)

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Cathepsin S activity controls ischemia-induced neovascularization in mice. Li X, Cheng XW, Hu L, et al. Int. J. Cardiol. 183, 198-208, (2015)

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A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Young CN, Sinadinos A, Lefebvre A, et al. Autophagy 11(1), 113-30, (2015)

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Potassium transporter TRH1 subunits assemble regulating root-hair elongation autonomously from the cell fate determination pathway. Daras G, Rigas S, Tsitsekian D, et al. Plant Sci. 231, 131-7, (2015)

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Tsetse GmmSRPN10 has anti-complement activity and is important for successful establishment of trypanosome infections in the fly midgut. Ooi CP, Haines LR, Southern DM, et al. PLoS Negl. Trop. Dis. 9(1), e3448, (2015)

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Preferential expression of a bromoperoxidase in sporophytes of a red alga, Pyropia yezoensis. Matsuda R, Ozgur R, Higashi Y, et al. Mar. Biotechnol. 17(2), 199-210, (2015)

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The Cloning and Functional Characterization of Peach CONSTANS and FLOWERING LOCUS T Homologous Genes PpCO and PpFT. Zhang X, An L, Nguyen TH, et al. PLoS ONE 10(4), e0124108, (2015)

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Superoxide dismutases, SOD1 and SOD2, play a distinct role in the fat body during pupation in silkworm Bombyx mori. Nojima Y, Ito K, Ono H, et al. PLoS ONE 10(2), e0116007, (2015)

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Comparative proteomic and biochemical analyses reveal different molecular events occurring in the process of fiber initiation between wild-type allotetraploid cotton and its fuzzless-lintless mutant. Yao Y, Zhang B, Dong CJ, et al. PLoS ONE 10(2), e0117049, (2015)

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22q11.2 deletion status and disease burden in children and adolescents with tetralogy of Fallot. Mercer-Rosa L, Paridon SM, Fogel MA, et al. Circ. Cardiovasc. Genet. 8(1), 74-81, (2015)

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Transpapillary drug delivery to the breast. Dave K, Averineni R, Sahdev P, et al. PLoS ONE 9(12), e115712, (2014)

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Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Van Laar VS, Roy N, Liu A, et al. Neurobiol. Dis. 74, 180-93, (2015)

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MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells. Zhang H, Tang J, Li C, et al. Cancer Lett. 356(2 Pt B), 781-90, (2015)

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Identification of autophagy-related genes ATG4 and ATG8 from wheat (Triticum aestivum L.) and profiling of their expression patterns responding to biotic and abiotic stresses. Pei D, Zhang W, Sun H, et al. Plant Cell Rep. 33(10), 1697-710, (2014)

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Spatial gene expression analysis in tomato hypocotyls suggests cysteine as key precursor of vascular sulfur accumulation implicated in Verticillium dahliae defense. Klug K, Hogekamp C, Specht A, et al. Physiol. Plant. 153(2), 253-68, (2015)

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DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing. Diotti R, Kalan S, Matveyenko A, et al. Mol. Cancer Res. 13(3), 402-10, (2015)

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A validated UPLC-MS/MS assay using negative ionization mode for high-throughput determination of pomalidomide in rat plasma. Iqbal M, Ezzeldin E, Al-Rashood KA, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984, 76-82, (2015)

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Signaling via the transcriptionally regulated activin receptor 2B is a novel mediator of neuronal cell death during chicken ciliary ganglion development. Koszinowski S, Buss K, Kaehlcke K, et al. Int. J. Dev. Neurosci. 41, 98-104, (2015)

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy Lombard, D.B., et al. Proc. Natl. Acad. Sci. U. S. A. 105, 3374-3379, (2008)

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ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. Zhang H, Lei Y, Yuan P, et al. PLoS ONE 9(5), e96418, (2014)

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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking. Liu R, Li J, Zhang T, et al. Autophagy 10(7), 1241-55, (2014)

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