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E8652 Sigma

EphA7/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: Cek11, Ebk, Ehk3, Hek11, Mdk1

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 85.7 kDa
  mol wt ~110 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Epha7(13841)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant human ephrin-A4/Fc in an ELISA assay.

Biochem/physiol Actions

Member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4, and ephrin-A5; involved in pattern formation and morphogenesis.

EphA7 (ephrin receptor A7) promotes normal synaptic functioning, and development of cortical dendrites and maturation of the spine, and acts as a guidance receptor during development and patterning of cortex. During initial stages of brain development, this receptor modulates cell apoptosis. It forms a multi-protein complex with tumor necrosis factor receptor 1 (TNFR1) and EphA5 to induce caspase-mediated cell death. In mice, it is induced by Dlx5 and Msx2, which are homeodomain-containing transcription factors. It therefore, regulates the morphogenesis of cranial neural tube, by controlling the cell adhesion. In mice, it also regulates the contouring of corticothalamic (CT) mapping. It plays the role of tumor-suppression in follicular lymphoma (FL), and thus has potential as a therapeutic target.

Other Notes

Extracellular domain of mouse EphA7 (amino acids 1-549) fused by means of a polypeptide linker to the Fc region of human IgG1 that is histidine-tagged at the C-terminus.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

General description

EphA7 (ephrin receptor A7) is a receptor tyrosine kinase (RTK), which belongs to a 16 member family of ephrin receptors. This family is divided into two classes A and B. EphA5 belongs to EphA group, which contains 10 members. The ligands to this group of receptors are glycosylphosphatidylinositol (GPI)-anchored named ephrin-A1-A6. The members of this family have an ephrin-binding domain in its N-terminal globular domain, succeeded by a linker region rich in cysteine and two fibronectin type III repeats in the exoplasmic domain. Its cytoplasmic domain consists of a juxtamembrane region, a conserved tyrosine kinase domain, an α-helical C-terminal domain, and a PDZ domain-binding domian.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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