• USA Home
  • E8755 - Erythromycin ethyl succinate

EMAIL THIS PAGE TO A FRIEND

E8755 Sigma

Erythromycin ethyl succinate

Purchase

Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
solubility   ethanol: soluble50 mg/mL
antibiotic activity spectrum   Gram-positive bacteria

Description

Application

Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae1. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes2 and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium3.

Biochem/physiol Actions

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

Price and Availability

Customers Also Viewed

European Pharmacopoeia (EP) Reference Standard

Erythromycin ethyl succinate

United States Pharmacopeia (USP) Reference Standard

Erythromycin ethyl succinate

European Pharmacopoeia (EP) Reference Standard

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
36
WGK Germany 
2
RTECS 
WM9800000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates [In Process Citation] KP Klugman, T Capper, et al. J. Antimicrob. Chemother. 42, 729-734, (1998)

Loading...


2. Down-regulation of motilin receptors on rabbit colon myocytes by chronic oral erythromycin SD Bologna, WL Hasler, et al. J. Pharmacol. Exp. Ther. 266, 852, (1993)

Loading...


3. Mutants carrying conditionally lethal mutations in outer membrane genes omsA and firA (ssc) are phenotypically similar, and omsA is allelic to firA. R Vuorio and M Vaara J. Bacteriol. 174, 7090-7097, (1992)

Loading...


[Erythromycin ethylsuccinate obtaining possibilities]. Stan CD, Stefanache A, Tântaru G, et al. Rev. Med. Chir. Soc. Med. Nat. Iasi. 112(4), 1104-9, (2008)

Loading...


[Specific ototoxic effects of monomycin in immature animals]. Bogomil'skiĭ MR, Dreval' AA, D'iakonova IN, et al. Vestn. Otorinolaringol. (5), 26-9, (2009)

Loading...


Pharmacokinetics of erythromycin ethylsuccinate after intragastric administration to healthy foals. Lakritz J, Wilson WD, Marsh AE, et al. Vet. Ther. 3(2), 189-95, (2002)

Loading...


[A case of diffuse panbronchiolitis]. Chen BZ, Xiang XD, and Chen P Hunan Yi Ke Da Xue Xue Bao 25(6), 534, 552, 560, (2000)

Loading...


Antibiotics for whooping cough (pertussis). Altunaiji S, Kukuruzovic R, Curtis N, et al. Cochrane Database Syst. Rev. (3), CD004404, (2007)

Loading...


Construction of universal quantitative models for determination of roxithromycin and erythromycin ethylsuccinate in tablets from different manufacturers using near infrared reflectance spectroscopy. Feng YC and Hu CQ J. Pharm. Biomed. Anal. 41(2), 373-84, (2006)

Loading...


Prokinetic effects of erythromycin after antimotion sickness drugs. Stewart JJ, Wood MJ, Parish RC, et al. J. Clin. Pharmacol. 40(4), 347-53, (2000)

Loading...


Comparison of the effect of azithromycin versus erythromycin on antroduodenal pressure profiles of patients with chronic functional gastrointestinal pain and gastroparesis. Moshiree B, McDonald R, Hou W, et al. Dig. Dis. Sci. 55(3), 675-83, (2010)

Loading...


Interaction of erythromycin ethylsuccinate and acetaminophen with protein fraction of extracellular polymeric substances (EPS) from various bacterial aggregates. Métivier R, Bourven I, Labanowski J, et al. Environ. Sci. Pollut. Res. Int. 20(10), 7275-85, (2013)

Loading...


Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: possible role of CYP3A4 and P-glycoprotein inhibition by curcumin. Cho YA, Lee W, and Choi JS Pharmazie 67(2), 124-30, (2012)

Loading...


Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs. Albarellos GA, Kreil VE, Ambros LA, et al. J. Vet. Pharmacol. Ther. 31(6), 496-500, (2008)

Loading...


Nondestructive quantitative analysis of erythromycin ethylsuccinate powder drug via short-wave near-infrared spectroscopy combined with radial basis function neural networks. Qu N, Li X, Dou Y, et al. Eur. J. Pharm. Sci. 31(3-4), 156-64, (2007)

Loading...


Dose uniformity and redispersibility of pharmaceutical suspensions 2: assessment of three commercial erythromycin ethyl succinate oral liquids. Deicke A and Süverkrüp R Eur. J. Pharm. Biopharm. 49(1), 73-8, (2000)

Loading...


Simultaneous determination of erythromycin ethylsuccinate and its metabolite erythromycin in human plasma using liquid chromatography-electrospray ionization mass spectrometry for clinical study. Gu Y, Wang G, and Sun J J. Pharm. Biomed. Anal. 40(3), 737-43, (2006)

Loading...


Special feature: radiological case of the month. Denouement and discussion: acute disseminated encephalomyelitis. Semnani H, Reminajes AV, and Tavakoli Z Arch. Pediatr. Adolesc. Med. 154(12), 1269-70, (2000)

Loading...


Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications. Liu YM, Shi YM, Liu ZL, et al. J. Sep. Sci. 33(9), 1305-11, (2010)

Loading...


Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution. Hassanzadeh A, Barber J, Morris GA, et al. J. Phys. Chem. A 111(40), 10098-104, (2007)

Loading...


Femtosecond IR spectroscopy of peroxycarbonate photodecomposition: S1-lifetime determines decarboxylation rate. Reichardt C, Schroeder J, and Schwarzer D J. Phys. Chem. A 111(40), 10111-8, (2007)

Loading...


A validated spectrofluorometric assay for the determination of certain macrolide antibiotics in pharmaceutical formulations and spiked biological fluids. El-Rabbat N, Askal HF, Khashaba PY, et al. J. AOAC Int. 89(5), 1276-87, (2006)

Loading...


Topical corticosteroid-induced acne. Three treatment strategies to break the 'addiction' cycle. Brodell RT and O'Brien MJ Postgrad. Med. 106(6), 225-6, 229, (1999)

Loading...


Open-Label, parallel-group, multicenter, randomized study of cefprozil versus erythromycin in children with group A streptococcal pharyngitis/tonsillitis. Brook I, Aronovitz GH, and Pichichero ME Clin. Ther. 23(11), 1889-900, (2001)

Loading...


Cholestasis and liver cell damage due to hypersensitivity to erythromycin stearate--recurrence following therapy with erythromycin succinate. Horn S, Aglas F, and Horina JH Wien. Klin. Wochenschr. 111(2), 76-7, (1999)

Loading...


Multiple aphthoid syphilitic chancres of the oral cavity. Veraldi S, Lunardon L, Persico MC, et al. Int. J. STD AIDS 19(7), 486-7, (2008)

Loading...


SCN5A R1193Q polymorphism associated with progressive cardiac conduction defects and long QT syndrome in a Chinese family. Sun A, Xu L, Wang S, et al. J. Med. Genet. 45(2), 127-8, (2008)

Loading...


Familial cases presenting very early onset autosomal dominant Alzheimer's disease with I143T in presenilin-1 gene: implication for genotype-phenotype correlation. Arai N, Kishino A, Takahashi Y, et al. Neurogenetics 9(1), 65-7, (2008)

Loading...


Antibiotics for whooping cough (pertussis). Altunaiji S, Kukuruzovic R, Curtis N, et al. Cochrane Database Syst. Rev. (1), CD004404, (2005)

Loading...


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?