|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae1. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes2 and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium3.
Erythromycin ethyl succinate inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P342 + P311|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||42/43|
|Safety Statements (Europe)||36|
1. Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates [In Process Citation] KP Klugman, T Capper, et al. J. Antimicrob. Chemother. 42, 729-734, (1998)
3. Mutants carrying conditionally lethal mutations in outer membrane genes omsA and firA (ssc) are phenotypically similar, and omsA is allelic to firA. R Vuorio and M Vaara J. Bacteriol. 174, 7090-7097, (1992)
Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: possible role of CYP3A4 and P-glycoprotein inhibition by curcumin. Cho YA, Lee W, and Choi JS Pharmazie 67(2), 124-30, (2012)
Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications. Liu YM, Shi YM, Liu ZL, et al. J. Sep. Sci. 33(9), 1305-11, (2010)
Comparison of the effect of azithromycin versus erythromycin on antroduodenal pressure profiles of patients with chronic functional gastrointestinal pain and gastroparesis. Moshiree B, McDonald R, Hou W, et al. Dig. Dis. Sci. 55(3), 675-83, (2010)
Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs. Albarellos GA, Kreil VE, Ambros LA, et al. J. Vet. Pharmacol. Ther. 31(6), 496-500, (2008)
Familial cases presenting very early onset autosomal dominant Alzheimer's disease with I143T in presenilin-1 gene: implication for genotype-phenotype correlation. Arai N, Kishino A, Takahashi Y, et al. Neurogenetics 9(1), 65-7, (2008)
Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution. Hassanzadeh A, Barber J, Morris GA, et al. J. Phys. Chem. A 111(40), 10098-104, (2007)
Nondestructive quantitative analysis of erythromycin ethylsuccinate powder drug via short-wave near-infrared spectroscopy combined with radial basis function neural networks. Qu N, Li X, Dou Y, et al. Eur. J. Pharm. Sci. 31(3-4), 156-64, (2007)
A validated spectrofluorometric assay for the determination of certain macrolide antibiotics in pharmaceutical formulations and spiked biological fluids. El-Rabbat N, Askal HF, Khashaba PY, et al. J. AOAC Int. 89(5), 1276-87, (2006)
Construction of universal quantitative models for determination of roxithromycin and erythromycin ethylsuccinate in tablets from different manufacturers using near infrared reflectance spectroscopy. Feng YC and Hu CQ J. Pharm. Biomed. Anal. 41(2), 373-84, (2006)
Simultaneous determination of erythromycin ethylsuccinate and its metabolite erythromycin in human plasma using liquid chromatography-electrospray ionization mass spectrometry for clinical study. Gu Y, Wang G, and Sun J J. Pharm. Biomed. Anal. 40(3), 737-43, (2006)
Open-Label, parallel-group, multicenter, randomized study of cefprozil versus erythromycin in children with group A streptococcal pharyngitis/tonsillitis. Brook I, Aronovitz GH, and Pichichero ME Clin. Ther. 23(11), 1889-900, (2001)
Special feature: radiological case of the month. Denouement and discussion: acute disseminated encephalomyelitis. Semnani H, Reminajes AV, and Tavakoli Z Arch. Pediatr. Adolesc. Med. 154(12), 1269-70, (2000)
Dose uniformity and redispersibility of pharmaceutical suspensions 2: assessment of three commercial erythromycin ethyl succinate oral liquids. Deicke A and Süverkrüp R Eur. J. Pharm. Biopharm. 49(1), 73-8, (2000)
Cholestasis and liver cell damage due to hypersensitivity to erythromycin stearate--recurrence following therapy with erythromycin succinate. Horn S, Aglas F, and Horina JH Wien. Klin. Wochenschr. 111(2), 76-7, (1999)
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