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E8755 Sigma

Erythromycin ethyl succinate

Description

Application

Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae1. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes2 and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium3.

Biochem/physiol Actions

Erythromycin ethyl succinate inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

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Erythromycin ethyl succinate

United States Pharmacopeia (USP) Reference Standard

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