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E9012 Sigma

Endothelin 2 human

≥97% (HPLC), powder

Synonym: ET-2

  • CAS Number 123562-20-9

  • Empirical Formula (Hill Notation) C115H160N26O32S4

  • Molecular Weight 2546.92

  •  MDL number MFCD00133306

  •  PubChem Substance ID 24894687

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Properties

Related Categories Agonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Endothelin - Receptor Agonists,
InChI Key   MLFJHYIHIKEBTQ-IYRKOGFYSA-N
assay   ≥97% (HPLC)
form   powder
color   white
storage temp.   −20°C
Gene Information   human ... EDN2(1907)

Description

Biochem/physiol Actions

Endothelin-2 (ET-2) has a regulatory role in multiple cancer types, such as breast and clear cell renal cell carcinoma (ccRCC). It is overexpressed during early stages of non-metastasized ccRCC, and is thought have a role in the progression of the same. It is a hypoxia-related factor, and might have protective action against cell death in neuronal diseases. It acts as a ligand for ET-A and ET-B receptors, which results in vasoconstriction. A985 polymorphism in this gene is thought play a protective role in cardiovascular diseases, but it acts as a susceptibility factor in atrial fibrillation in hypertrophic cardiomyopathy patients. In neural retina, it suppresses angiogenesis, and facilitates the tip cell state in endothelial cells.

General description

Endothelin-2 (ET-2) is a member of the endothelin family, which also includes ET-1 and ET-3. ET-2 is the human ortholog of mouse and rat vasoactive intestinal contractor (VIC). These peptides are characterized by two disulfide linkages. ET-2 is predominantly expressed in cerebrum, stomach, intestine, ovary, uterus and testis.

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Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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