• USA Home
  • E9527 - EphB3/Fc Chimera from mouse

EMAIL THIS PAGE TO A FRIEND
E9527 Sigma

EphB3/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: Cek10, Hek2, Mdk5, Sek4, Tyro6

Purchase

Properties

Related Categories Angiogenesis, Application Index, Biochemicals and Reagents, Cancer Research, Cell Biology,
recombinant   expressed in NSO cells
assay   >95% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 82.8 kDa
  mol wt ~100 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Ephb3(13845)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse ephrin-B1/Fc in an ELISA assay.

Biochem/physiol Actions

Member of Eph receptor tyrosine kinase family shown to bind ephrin-B1, ephrin-B2, and ephrin-B3; involved in pattern formation and morphogenesis, and in arterial/venous demarcation of the developing vasculature.

EphB3 (Epherin receptor B3) is involved in the development and plasticity of glutamatergic synapses, and their interaction with NMDA receptor. It can also regulate the processing of acute inflammatory pain, and mechanical allodynia as a result of nerve crush. In damaged adult cortex, this receptor promotes receptor-mediated cell apoptosis, which in turn is repealed by the action of ephrinB3 on EphB3. EphB3 and EphB2 reverse signaling plays an essential role for the formation of ventral cochlear nucleus (VCN) projections to medial nucleus of the trapezoid body (MNTB). It also plays a key role in the modulation of the survival of thymic epithelial cells (TECs), and their inactivation is related to elevated apoptotic incidence.

Other Notes

Extracellular domain of mouse EphB3 (amino acids 1-530) fused to the C-terminal 6X histidine-tagged Fc region of human IgG1 via a polypeptide linker.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM Tris, pH 8.0.

General description

EphB3 (Epherin receptor B3) is a receptor tyrosine kinase (RTK), which belongs to a 13 member family of ephrin receptors. This family is divided into two classes A and B. EphB3 belongs to EphB group, which contains five members. The ligands to this group of receptors are named ephrin-B1-B3. It is a bidirectional functioning membrane protein.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?