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E9530 Sigma

Erythropoietin from mouse

recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder, cell culture tested

Synonym: EPO

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, Erythropoietin,
recombinant   expressed in NSO cells
assay   ≥90% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt ~36 kDa by SDS-PAGE
  predicted mol wt 18.6 kDa
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   mouse ... Epo(13856)

Description

Analysis Note

The biological acitivity is measured by its ability to stimulate cell proliferation using TF-1 cell line.

Biochem/physiol Actions

Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.

EPO (erythropoietin) plays an essential role in the growth and differentiation of erythrocyte progenitor cells. It is involved in the pathogenesis of myomatous erythrocytosis syndrome, which is characterized by erythrocytosis and myomatous uterus. It acts as a ligand for a homodimer of EPO-receptor (Epo-R), which is localized to the surface of immature erythroid cells. This interaction leads to inhibition of apoptosis and facilitation of cell proliferation and differentiation to mature erythrocytes.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

General description

EPO (erythropoietin) gene is localized to human chromosome 7q22. This protein is predominantly produced by the cortex cells of kidney, as well as a variety of tissues including female reproductive organs. It is a glycoprotein, which has a molecular weight of 34kDa. It is produced as a 193-amino acid precursor protein, which is cleaved to produce a secreted protein of 166-amino acid.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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