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E9777 Sigma

EphB6/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: Mep

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Properties

Related Categories Angiogenesis, Application Index, Biochemicals and Reagents, Cancer Research, Cell Biology,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 87.3 kDa
  mol wt ~100 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Ephb6(13848)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse ephrin-B2/Fc in an ELISA assay.

Biochem/physiol Actions

Member of Eph receptor tyrosine kinase family shown to bind ephrin-B1 and ephrin-B2; involved in pattern formation and morphogenesis.

EPHB6 (ephrin receptor B6) is a member of EPHB receptor family, the members of which play a role in self-renewal of intestinal epithelium, development of uro-rectal tract, insulin secretion from pancreatic β cells, development, maintenance and repair of bone, regulation of hypoxia-induced red blood cell synthesis, glomerular filtration, clotting and homeostasis of vestibular endolymph fluid in the inner ear. EPHB6 receptor acts in co-ordination with sex hormones such as testosterone to control the contractility of vascular smooth muscle cells, and thus regulates the blood pressure.

Other Notes

Extracellular domain of mouse EphB6 (amino acids 1-587) fused to the C-terminal 6X histidine-tagged Fc region of human IgG1 via a polypeptide linker.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

General description

EPHB6 (ephrin receptor B6) belongs to the largest receptor tyrosine kinase family called EPHB, and the members act as receptors for cell surface ephrin (eph) proteins. This protein is expressed on vascular smooth muscle cells (VSMC), lymphocytes and T-cells.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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