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E9902 Sigma

Ephrin-A1/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: B61, EFL-1, LERK-1

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Properties

Related Categories Angiogenesis, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 46.8 kDa
  mol wt 50-55 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Efna1(13636)

Description

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.

Biochem/physiol Actions

Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.

EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.

Other Notes

Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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