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F0176 Sigma

Anti-FLI-1 antibody produced in sheep

fractionated antiserum, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Gene Regulation, Antibodies to Common Transcription Factors, Antibodies to Transcription Factors,
species reactivity   human, mouse
application(s)   western blot: suitable using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
clone   polyclonal
antibody form   fractionated antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 52 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... FLI1(2313)
mouse ... Fli1(14247)
biological source   sheep
conjugate   unconjugated



GST fusion protein of the N-terminus of Fli-1 corresponding to amino acids 1-239.

Physical form

Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide


Anti-FLI-1 antibody produced in sheep is suitable for western blotting using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.

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Biochem/physiol Actions

Friend leukemia integration 1 transcription factor (FLI1) is a protein that is encoded by the FLI1 gene in humans and is a member of Ets transcription factor family. It is a proto-oncogene and located on human chromosome 11q23-24. FLI1 may be involved in human sarcomas, leukemias and lymphomas. It may play an important role in the posttranscriptional regulation of the Fli-1 transcript. Alteration in the transcriptional activation function of Fli-1 may be responsible for human malignancies. It is a novel ETS transcription factor involved in gene fusions in prostate cancer.

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Safety Information

WGK Germany  2
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