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F0301 Sigma

Monoclonal Anti-CD56-FITC antibody produced in mouse

clone C5.9, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-NKH-1, Monoclonal Anti-CD56

Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood,
species reactivity   human
application(s)   flow cytometry: suitable
clone   C5.9, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2bκ
mol wt   antigen mol wt 150 kDa
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... NCAM1(4684)
biological source   mouse
conjugate   FITC conjugate

Description

Immunogen

A cloned human NK cell line termed JT3

General description

Prepared by conjugation of fluorescein isothiocyanate isomer 1 (FITC). This green dye is efficiently excited at 495 nm and emits at 525 nm.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 0.2% gelatin and 0.08% sodium azide.

Application

Monoclonal Anti-CD56-FITC antibody produced in mouse is suitable for fluorescence microscopy. It was also used for flow cytometric analysis.

Features and Benefits

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Biochem/physiol Actions

Neural Cell Adhesion Molecule (NCAM or the cluster of differentiation CD56) is a homophilic binding glycoprotein. It is expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. CD56 can also be expressed in normal immature granulocytes at different expression levels in regenerative bone marrow. It is associated with cardiac genes induced by metabolic stress and its expression is associated with worsening hemodynamic parameters and major metabolic genes. CD56 is involved in left ventricular remodeling and can be implicated in heart failure. It is is developmentally regulated and may have an important role in cardiac development.

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