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  • F0397 - Monoclonal Anti-Cytokeratin, pan−FITC antibody produced in mouse

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F0397 Sigma

Monoclonal Anti-Cytokeratin, pan−FITC antibody produced in mouse

clone PCK-26, purified immunoglobulin, buffered aqueous solution

Synonym: Monoclonal Anti-pan-Cytokeratin

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytokeratins,
species reactivity   lizard, goat, bovine, human, hamster, rat, carp, guinea pig, pig, rabbit, mouse, sheep, chicken, feline, canine, snake
application(s)   direct immunofluorescence: 1:25 using formalin-fixed, paraffin-embedded sections of human or animal tissues
  immunohistochemistry (frozen sections): suitable
clone   PCK-26, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C
biological source   mouse
conjugate   FITC conjugate

Description

Immunogen

cytokeratin from human epidermis.

General description

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Specificity

The antibody recognizes an epitope located on the Type II cytokeratins 1, 5, 6, and 8. PCK-26 is a broad spectrum antibody which reacts specifically with a variety of normal, reactive, and neoplastic epithelial tissues. The antibody reacts with simple, cornifying, and non-cornifying squamous epithelia and pseudostratified epithelia.

Application

Monoclonal Anti-Cytokeratin, pan-FITC antibody produced in mouse is suitable for direct immunofluorescence at a dilution of 1:25 using formalin-fixed, paraffin-embedded sections of human or animal tissues and immunohistochemistry (frozen sections).

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