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F0675 Sigma

Anti-Fractalkine antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CX3CL1

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL using human tissue
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CX3CL1(6376)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human fractalkine/CX3CL1 chemokine domain, expressed in E. coli.

General description

Fractalkine, also known as neurotactin is an atypical chemokine, synthesized as a membrane-bound molecule containing a chemokine domain presented on a mucin-like stalk which facilitates the direct capture of circulating leukocytes. It also has a crucial role in all stages of atherogenesis like recruitment, retention and survival of monocytes in early atherosclerotic lesions along with the foam cell persistence in advanced plaques. Anti-Fractalkine antibody can be used in neutralization of biological activity of recombinant human fractalkine. It can also be used in immunohistochemistry. Goat anti-Fractalkine antibody has shown 35% (approx.) cross-reactivity with recombinant mouse fractalkine/CX3CL1 and 15% (approx.) cross-reactivity with recombinant rat CX3CL1. This antibody also has 5% cross-reacitivity with recombinant human eotaxin, recombinant human MCP-1, recombinant mouse MARC, recombinant human MCP-2, recombinant human 6Ckine and recombinant mouse eotaxin.

Physical form

Lyophilized from 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.

Specificity

The antibody will neutralize the biological activity of recombinant human fractalkine/CX3CL1. Based on ELISA, the antibody shows ~35% cross-reactivity with recombinant mouse fractalkine/CX3CL1 and 15% cross-reactivity with recombinant rat CX3CL1. The antibody also shows 5% cross-reacitivity with recombinant human eotaxin, recombinant mouse eotaxin, recombinant human MCP-1, recombinant human MCP-2, recombinant human 6Ckine, and recombinant mouse MARC.

Application

Anti-Fractalkine antibody can be used in western blotting and ELISA.

Features and Benefits

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