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F0807 Sigma

Anti-FNTB (276-290) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Farnesyltransferase subunit β, Anti-FPTB



Related Categories Alphabetical Index, Antibodies, FK-FO, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~49 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... FNTB(2342)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 276-290 of human FNTB

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-FNTB (276-290) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

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Biochem/physiol Actions

Protein farnesyltransferase subunit β is an enzyme encoded by the FNTB gene in humans and is located on human chromosome bands 14q23-q24. It helps in catalyzing the biologically relevant lipidation of cellular proteins. FTase may play an important role in the genesis and development of primary liver cancer (PLC). It may act as a reliable marker for the metastatic activity gained by liver tumor cells. FTase may be used clinically in predicting metastatic recurrence of PLC. Farnesyl protein transferase (FPTase) inhibitors (FTIs) were also developed as potential anticancer agents targeting the ras oncogene and also for parasitic infections.

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