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F112 Sigma

(+)-Fenfluramine hydrochloride

Synonym: (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, F,
InChI Key   ZXKXJHAOUFHNAS-FVGYRXGTSA-N
form   powder
drug control   USDEA Schedule IV
color   white to off-white
solubility   H2O: soluble10 mg/mL
storage temp.   room temp

Description

Other Notes

Active isomer

Biochem/physiol Actions

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
SH6824000
Protocols & Articles

Articles

History of Biogenic Amine Use for Treating Obesity

The discovery of ephedrine (Product No. E2750) in the 1930s led to the synthesis of amphetamines. Initially utilized as stimulants, they were soon shown to exhibit food intake and appetite suppressin...
Keywords: Obesity

Peer-Reviewed Papers
15

References

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