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F1175 Sigma

Follistatin 300 human

≥90% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, cell culture tested

Synonym: FS 300

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Properties

Related Categories Activins, Activins and Inhibins, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
recombinant   expressed in Sf21 cells
assay   ≥90% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... FST(10468)

Description

Analysis Note

The biological activity is measured by its ability to neutralize activin-induced bioactivity on K562 cells (erythroid differentiation).

Biochem/physiol Actions

High-affinity activin-binding protein that can act as an activin antagonist.

FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.

Packaging

25 μg in glass insert

Physical form

Lyophilized from a solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Application

FST (follistatin) has been used for trophoblast fusion assay and the measure of hCG (human chorionic gonadotropin) concentration in hormone assays. It is also suitable for the development of chondrocytes from hESc (human embryonic stem cells) by a new 3-Stage directed differentiation protocol (DDP).

General description

FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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