|Related Categories||Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,|
|solubility||ethanol: soluble0.33 mg/mL|
|DMSO: >10 mg/mL|
|Gene Information||human ... CYP1A2(1544)|
Furafylline is a methyl xanthine derivative with longer duration of action than theophylline and an inhibitor of cytochrome P4501A2.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F124.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Characterization of glutathione conjugates of duloxetine by mass spectrometry and evaluation of in silico approaches to rationalize the site of conjugation for thiophene containing drugs. Wu G, Vashishtha SC, and Erve JC Chem. Res. Toxicol. 23(8), 1393-404, (2010)
Effect of diethyldithiocarbamate (DDC) and ticlopidine on CYP1A2 activity and caffeine metabolism: an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes. Kot M and Daniel WA Pharmacol. Rep. 61(6), 1216-20, (2009)
Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages. Lacour S, Antonios D, Gautier JC, et al. J. Immunotoxicol. 6(2), 84-93, (2009)
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation? Fairman DA, Collins C, and Chapple S Drug Metab. Dispos. 35(12), 2159-65, (2007)
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543. Khojasteh-Bakht SC, Rossulek MI, Fouda HG, et al. Xenobiotica 33(12), 1201-10, (2003)
Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes. Yoda N, Emoto C, Date S, et al. Xenobiotica 42(8), 719-30, (2012)
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Kazui M, Nishiya Y, Ishizuka T, et al. Drug Metab. Dispos. 38(1), 92-9, (2010)
Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry. He YQ, Yang L, Liu Y, et al. Acta Pharmacol. Sin. 30(10), 1462-70, (2009)
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Guo J, Nikolic D, Chadwick LR, et al. Drug Metab. Dispos. 34(7), 1152-9, (2006)
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat. Kobayashi K, Urashima K, Shimada N, et al. Drug Metab. Dispos. 31(7), 833-6, (2003)
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