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F1302 Sigma

FADD human

>85% (SDS-PAGE), recombinant, expressed in E. coli (maltose binding protein (MBP) fusion protein), buffered aqueous solution

Synonym: Fas Associated Death Domain, Mort-1

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Properties

Related Categories Adaptor Protein, Adaptor Proteins and Antibodies, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
recombinant   expressed in E. coli (maltose binding protein (MBP) fusion protein)
assay   >85% (SDS-PAGE)
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... FADD(8772)

Description

Analysis Note

Binds caspase 8 from a jurkat cell extract.

Biochem/physiol Actions

An apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. It contains a carboxy-terminal death domain, which interacts with the Fas receptor death domain while its NH2-terminal contains a death effector domain (DED) recruiting caspase-8 to the death inducing signaling complex (DISC) thus initiating apoptotic caspase cascade.
Recently FADD was implicated in non-apoptotic cellular pathways, such as the regulation of cell cycle machinery in T lymphocytes, which was found to be connected to its phosphorylation state, and the FasL/TRAIL-induced transcriptional activation of c-fos protooncogene.
FADD was also found to interact with hepatitis C virus core protein in HEK-293 cell line.

Packaging

250 μg in glass bottle

Physical form

Solution containing 20 mM Tris pH 7.4, 250 mM NaCl, 1 mM EDTA, 1 mM DTT, and 10% glycerol.

Price and Availability


Flow Cytometry Instruments
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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