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F137 Sigma

Anti-c-Fos antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Gene Regulation, Antibodies to Common Transcription Factors, Antibodies to Transcription Factors,
species reactivity   mouse
application(s)   western blot (chemiluminescent): 10 μg/mL using mouse NIH3T3 cells
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
mol wt   antigen mol wt 50-60 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... FOS(2353)
mouse ... Fos(14281)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide derived from amino acids 4-17 from the N-terminal region of human and mouse c-Fos.

Physical form

Lyophilized from phosphate buffered saline containing 0.05% sodium azide.

Specificity

The antibody does not react with c-Fos in HeLa cells.

Preparation Note

Prepared using protein A.

Application

Anti-c-Fos antibody produced in rabbit is suitable for the following applications:
• Western blotting (chemiluminescent) at a concentration of 10μg/mL using mouse NIH3T3 cells
• Immunohistochemistry
• Tissue Immunofluorescence

Features and Benefits

Antibody Bioguarantee
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Reconstitution

Reconstitute with 100 μl deionized water.

Biochem/physiol Actions

c-Fos is a proto-oncogene, which is the human homolog of the retroviral oncogene v-fos. It is one of the essential transcription factors that helps in initiation of adipocyte differentiation. FOS protein expression in human glioma is found to be strong and probably plays a critical role in the progression of gliomas. c-Fos may be involved in regulating lipid synthesis. c-Fos is associated with prognosis of ovarian cancer (OvCa) by changing the adhesion of OvCa cells to peritoneal surfaces.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  nwg
Protocols & Articles

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Peer-Reviewed Papers
15

References

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