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F1802 Sigma

Fibroblast Growth Factor-8c from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: FGF-8c

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Description

Analysis Note

The biological activty is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.

Application

Fibroblast Growth Factor-8c from mouse is suitable for the prevention of cross-reaction in Western blot and SDS-PAGE for FGF2 protein.

Biochem/physiol Actions

FGF-8c plays a role in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system.

Fgf8 (fibroblast growth factor 8) plays an essential role in the development of dorsal raphe nucleus (DR), and is expressed in fetus in the developing anterior hindbrain. DR serotonergic neurons are born in this area of the brain, and this is achieved due to the formation of diffusion gradient by the secreted Fgf8 peptide. Failure of this results in loss of serotonergic neurons during brain development. A nonsense mutation in this gene is linked with isolated hypogonadotropic hypogonadism (IHH), with different degrees of olfactory phenotype and human gonadotropin-releasing deficiency.

General description

Fgf8 (fibroblast growth factor 8) is a member of the FGF family of proteins. This family was originally identified as fibroblast mitogen in bovine pituitary and brain. Both humans and mice, have six to seven subfamilies of FGF protein containing 22 members. FGF gene is composed of three exons, and the first exon is alternatively spliced to produce four variants. This gene is expressed in embryonic organs such as brain, eye, ear, hearts and limbs.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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