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F1888 Sigma

Monoclonal Anti-Filamin antibody produced in mouse

clone FIL-2, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Actin-associated Proteins/Myosin, Antibodies to Cell and Organelle Proteins,
species reactivity   chicken
application(s)   indirect immunofluorescence: 1:200 using cultured chicken fibroblasts
  microarray: suitable
  western blot: suitable
clone   FIL-2, monoclonal
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt ~250 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   chicken ... LOC395260(395260)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

filamin from chicken gizzard.

General description

Filamins is a high molecular mass, large flexible actin cross-linking protein expressed in muscle and non-muscle cells. It has a molecular weight of approximately 250kDa and forms dimers in solution. The name filamins refers to its filamentous colocalization with actin stress fibers. It has an actin binding domain and a homodimerization domain.

Application

Anti-Filamin antibody is suitable for indirect immunofluorescence at a dilution of 1:200 by using cultured chicken fibroblasts, microarray, and western blot analysis.

Features and Benefits

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Biochem/physiol Actions

Filamin has been primarily identified from smooth muscle but it has also been identified in macrophages, neutrophils, platelets and other cell types. It binds to the ring zinc finger domain of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2).

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