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F2293 Sigma

Follicle Stimulating Hormone from porcine pituitary

Synonym: FSH, Follitropin, pFSH

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Follicle Stimulating Hormone (FSH), Hormones,
packaging   pkg of 50 unit per vial
solubility   H2O: soluble50 mg/mL
storage temp.   2-8°C
Gene Information   human ... FSHR(2492)
pig ... FSHB(396895)

Description

Biochem/physiol Actions

The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

FSH in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in this gene are more commonly found in patients with polycystic ovary syndrome (PCOS).

Other Notes

Two-chain glycoprotein hormone

Packaging

1 vial in serum bottle

5 vials in serum bottle

Unit Definition

One unit is the activity of 1 mg of Armour FSH Standard G-94 by the method of Steelman, S.L., and Pohley, F.M., Endocrinology, 53, 604 (1953).

Application

Follicle stimulating hormone from porcine pituitary has been used for the in vitro maturation, fertilization and co-culture of cumulus oocyte complex and the co-culture of primary germ and Sertoli cells obtained from adult rat testes.

General description

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH, hCG and TSH, which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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