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F3393 Sigma

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

fractionated antiserum, lyophilized powder

Synonym: Anti-FGF2, Anti-bFGF

Description

Immunogen

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Application

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit was used as inhibitory antibody to study the specific role of bFGF in differentiation of HUVECs. It was used to block the FGF2 receptor in tumor cell lines.

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Analysis Note

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Biochem/physiol Actions

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

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