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F3901 Sigma

Monoclonal Anti-Interleukin-4−Carboxyfluorescein antibody produced in mouse

clone 3007.11, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-IL-4, Monoclonal Anti-Interleukin-4

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Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Intracellular Cytokine Staining, Antibodies to Interleukins and Receptors,
species reactivity   human
application(s)   flow cytometry: suitable
clone   3007.11, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   wet ice
storage condition   protect from light
storage temp.   2-8°C
Gene Information   human ... IL4(3565)
biological source   mouse
conjugate   carboxyfluorescein conjugate

Description

Immunogen

recombinant human IL-4

Physical form

Solution in saline containing up to 0.5% bovine serum albumin and up to 0.1% of sodium azide as a preservative.

Specificity

The conjugates will identify and quantitate cells containing intracellular forms of human IL-4.

Preparation Note

Purified antibody is conjugated to carboxyfluorescein (FITC).

Features and Benefits

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Packaging

100 test in glass bottle

Biochem/physiol Actions

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The signaling stimulated by IL-4 by binding to its receptors leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 mediates endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. The coupling of Carboxyfluorescein to Anti-Interleukin-4 antibody allows for flow cytometry applications.

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Safety & Documentation

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment  dust mask type N95 (US), Eyeshields, Gloves
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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Peer-Reviewed Papers
15

References

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