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F3917 Sigma

Forskolin

For use in molecular biology applications

Synonym: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin

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Properties

Related Categories Biochemicals, Biochemicals and Reagents, Isoprenoids, Lipids, Molecular Biology,
biological source   from Coleus forskohlii
description   for activation of T cells
InChI Key   OHCQJHSOBUTRHG-KGGHGJDLSA-N
product line   BioReagent
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: soluble5 mg/mL (stable at least 6 months at room temperature)(lit.)
  ethanol: soluble
suitability   suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells
storage temp.   room temp

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

Packaging

10, 25 mg in poly bottle

General description

Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii.

Price and Availability


The Future of Bioimaging

Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QL6150000

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
How should I store a DMSO or ethanol solution of Product F3917, Forskolin?
Forskolin solutions at 5 mg/mL in either ethanol or DMSO have been found to be stable for at least 6 months at room temperature, as determined by HPLC analysis.
How can I make an aqueous solution of Product F3917, Forskolin?
Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and performing subsequent dilutions in water. Similar results were obtained with DMSO.
Will residual solvents inhibit forskolin activation of adenylate cyclase?
Various solvents, including ethanol, inhibit the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions, because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

Forskolin from Coleus forskohlii

T-cell activation is normally triggered by the interaction of a cell surface receptor to its specific ligand molecule. This binding event triggers the rapid hydrolysis of inositol phospholipids to di...
Keywords: Addition reactions, Centrifugation, Culture media, Enzyme-linked immunosorbent assay, Ligands, Phosphorylations

Peer-Reviewed Papers
15

References

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