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F4021 Sigma

Follicle Stimulating Hormone from human pituitary

~7,000 IU/mg (vs. W.H.O. reference preparation 83/575)

Synonym: FSH

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Follicle Stimulating Hormone (FSH), Hormones,
storage temp.   −20°C
Gene Information   human ... FSHB(2488), FSHR(2492)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS). In male fetus and neonates, it facilitates the proliferation of Sertoli cells. In pubescent males, it stimulates spermatogonia to undergo mitosis.

Other Notes

Two-chain glycoprotein hormone

Packaging

Package size based on protein content

Quality

Vial also contains 0.1 mg of salts from 0.05 M phosphate buffer, pH 7.4.

Application

Follicle stimulating hormone (FSH) from human pituitary has been used for-
• in vitro luteinization of Macaque granulosa cells
• luteal cell proliferation assay
• culturing of preantral follicle cells obtained from mice
• in vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice and
• culture of RAW264.7 cell line

General description

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where a subunit has resemblance to LH (luteinizing hormone), hCG (human chorionic gonadotropin) and TSH (thyrotropin-releasing hormone), which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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06693 Timestrip Plus -20 °C

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