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F4503 Sigma

Ferritin from equine spleen

Type I, saline solution

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Properties

Related Categories Antioxidants and Cytoprotectants, Cancer Research, Cancer Research Enzymes, Cell Biology, Cell Signaling and Neuroscience,
sterility   sterile-filtered
type   Type I
form   saline solution
mol wt   H subunit mol wt ~21 kDa
  L subunit mol wt ~19 kDa
color   red
cation traces   Cd: ≤1% (as % of ferritin)
storage temp.   2-8°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.

General description

A shell of 24 protein subunits (apoferritin) and a core Fe 3+ ions with a peptide MW of 440 kDa. Review of the ferritin-like superfamily of iron-storage proteins, virtually ubiquitous in life on earth.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What is the concentration of ferritin in solutions of Product F4503, Ferritin from equine spleen?
The concentration of ferritin is lot specific and can be found on the Certificate of Analysis (CofA) for the specific lot. To access the CofA, click on the following link: http://www.sigmaaldrich.com/catalog/search/AdvancedSearchPage
Has Product F4503, Ferritin from equine spleen, been cell culture tested?
The solution is sterile-filtered but has not been tested in cell culture.
Where is iron located in the ferritin molecule of Product F4503, Ferritin from equine spleen?
Iron is located in the core of the ferritin molecule consisting of 24 subunits. Up to 4500 iron ions can be contained in this core.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

HPLC Analysis of Proteins on SRT® SEC-1000, 30 cm x 7.8 mm I.D., 5 μm particles

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on SRT® SEC-1000, 30 cm x 7.8 mm I.D., 5 μm particles
Keywords: Chromatography, High performance liquid chromatography, Size-exclusion chromatography

HPLC Analysis of Proteins on SRT® SEC-300, 30 cm x 7.8 mm I.D., 5 μm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on SRT® SEC-300, 30 cm x 7.8 mm I.D., 5 μm
Keywords: Chromatography, High performance liquid chromatography, Size-exclusion chromatography

HPLC Analysis of Proteins on SRT® SEC-500, 30 cm x 7.8 mm I.D.

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on SRT® SEC-500, 30 cm x 7.8 mm I.D.
Keywords: Chromatography, High performance liquid chromatography, Size-exclusion chromatography

Peer-Reviewed Papers
15

References

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