|Related Categories||A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids|
|mp||280 °C (dec.)(lit.)|
M-Fluorotyrosine (m-Fluoro-DL-tyrosine) may be substituted for tyrosine in the biosynthesis of proteins such as β-galactosidases (Escherichia coli), bacteriorhodopsin and intestinal microvillar enzymes, eg. aminopeptidase N, to study the effect of halogenated tryosines on the proteins properties.
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|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||20/21/22|
|Safety Statements (Europe)||36|
Perturbation of intestinal microvillar enzyme biosynthesis by amino acid analogs. Evidence that dimerization is required for the transport of aminopeptidase N out of the endoplasmic reticulum. Danielsen EM. J. Biol. Chem. 265, 14566-14571, (1990)
Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine. Xiao G, Parsons JF, Tesh K, et al. J. Mol. Biol. 281(2), 323-39, (1998)
High-efficiency incorporation in vivo of tyrosine analogues with altered hydroxyl acidity in place of the catalytic tyrosine-14 of Delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: effects of the modifications on isomerase kinetics. Brooks B, Phillips RS, and Benisek WF Biochemistry 37(27), 9738-42, (1998)
6-[18F]fluoro-L-m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates. Jordan S, Eberling JL, Bankiewicz KS, et al. Brain Res. 750(1-2), 264-76, (1997)
3-Fluorotyrosine as a complementary probe of hemoglobin structure and dynamics: a (19)F-NMR study of Synechococcus sp. PCC 7002 GlbN. Pond MP, Wenke BB, Preimesberger MR, et al. Chem. Biodivers. 9(9), 1703-17, (2012)
Probing the coupling between proton and electron transfer in photosystem II core complexes containing a 3-fluorotyrosine. Rappaport F, Boussac A, Force DA, et al. J. Am. Chem. Soc. 131(12), 4425-33, (2009)
Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation. Seyedsayamdost MR, Yee CS, and Stubbe J Nat. Protoc. 2(5), 1225-35, (2007)
Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis. Seyedsayamdost MR, Reece SY, Nocera DG, et al. J. Am. Chem. Soc. 128(5), 1569-79, (2006)
Evaluating the potential of fluorinated tyrosines as spectroscopic probes of local protein environments: a UV resonance Raman study. Reid PJ, Loftus C, and Beeson CC Biochemistry 42(8), 2441-8, (2003)
Aldrich MSDS 1, 977:D / Corp MSDS 1 (1), 1731:A / FT-IR 2 (2), 2751:D / FT-IR 1 (2), 256:B / FT-NMR 1 (2), 1189:A / IR-Spectra (2), 873:H / IR-Spectra (3), 998:C / NMR-Reference 2 (2), 258:C / RegBook 1 (2), 1847:C / Sigma FT-IR 1 (1), 160:D / Structure Index 1, 296:D:3
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