FK-506 monohydrate
≥98% (HPLC)
DOWNLOAD MSDS (PDF)Synonym: Tacrolimus
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CAS Number 109581-93-3
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Empirical Formula (Hill Notation) C44H69NO12 · H2O
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Molecular Weight 822.03
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MDL number MFCD11045918
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PubChem Substance ID 24724482
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Popular Documents: Product Information Sheet (PDF)
Properties
| Related Categories | A to C, Bioactive Small Molecules, Biochemicals and Reagents, Calcineurin, Cell Biology, |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | DMSO: soluble20 mg/mL |
| storage temp. | −20°C |
| Gene Information | human ... FKBP1A(2280) |
Description
Biochem/physiol Actions
FK-506 is a potent immunosuppressant, neuroprotective and neuroregenerative, and in vitro T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
Price and Availability
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Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
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