|Related Categories||Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...|
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols.4 Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.5
Filipin III is the major component of 8 isomeric components in filipin.
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel1 and immobilized on nitrocellulose membranes.2 It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.3
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|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
1. Filipin staining of lipoproteins in polyacrylamide gels: sensitivity and photobleaching of the fluorophore and its use in a double staining method. Smejkal, G.B., and Hoff, H.F. Electrophoresis 15, 922-5, (1994)
A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Kozik P, Hodson NA, Sahlender DA, et al. Nat. Cell Biol. 15(1), 50-60, (2013)
Brain region-specific immunolocalization of the lipolysis-stimulated lipoprotein receptor (LSR) and altered cholesterol distribution in aged LSR+/- mice. Stenger C, Pinçon A, Hanse M, et al. J. Neurochem. 123(4), 467-76, (2012)
Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice. Calpe-Berdiel L, Zhao Y, de Graauw M, et al. Atherosclerosis 223(2), 332-41, (2012)
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells Okada, Y., et al. Carbohydr. Res., (2012)
Streptococcus suis capsular polysaccharide inhibits phagocytosis through destabilization of lipid microdomains and prevents lactosylceramide-dependent recognition. Houde M, Gottschalk M, Gagnon F, et al. Infect. Immun. 80(2), 506-17, (2012)
[Effect of cholesterol on the functional activity of proteins responsible for the resistance of human lymphocytes to xenobiotics]. Tamashevskiĭ AV, Kozlova NM, Goncharova NV, et al. Biofizika 56(3), 455-64, (2011)
The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. Miyamoto KT, Kitani S, Komatsu M, et al. Microbiology 157(Pt 8), 2266-75, (2011)
Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis Jinesh, G.G., et al. Cell Death Differ., (2012)
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